Dasatinib inhibits peripapillary scleral myofibroblast differentiation
نویسندگان
چکیده
منابع مشابه
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.
Dasatinib is a novel, potent, ATP-competitive inhibitor of Bcr-Abl, cKIT, and Src family kinases that exhibits efficacy in patients with imatinib-resistant chronic myelogenous leukemia. Dasatinib treatment is associated with mild thrombocytopenia and an increased risk of bleeding, but its biological effect on megakaryocytopoiesis and platelet production is unknown. In this study, we show that d...
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PURPOSE To characterize the thickness of the peripapillary sclera in perfusion-fixed normal monkey eyes so as to build accurate computational models of intraocular pressure (IOP)-related stress and strain within these tissues. METHODS Nine rhesus monkeys were perfusion fixed, each with one normal eye set to an IOP of 10 mm Hg by manometer. A 6-mm-diameter specimen containing the optic nerve h...
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in healthy volunteers. Levocetirizine reduces plasmatic level of IL-6 (1.19 versus 1.006, P 1⁄4 0.0097) and IL-8 (8.90 versus 6.90, P 1⁄4 0.0003) after 4 weeks treatment, while Desloratadine has influence only IL-6 level (1.68 versus 1.36, P 1⁄4 0.0038). The intergroup analysis revealed no significant difference between these 2 drugs regarding IL-6 (P 1⁄4 0.36) and IL-8 (P 1⁄4 0.25). Conclusion...
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BACKGROUND Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation of profibrotic myofibroblasts is a crucial process for fibrotic remodeling in IPF. Recent findings show participation of autophagy/mitophagy, part of the lysosomal degradation machinery, in IPF pathogenesis. Mitophagy has bee...
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Myofibroblast differentiation is a key process in pathogenesis of fibrotic diseases. Cardiac glycosides (ouabain, digoxin) inhibit Na(+)-K(+)-ATPase, resulting in increased intracellular [Na(+)]-to-[K(+)] ratio in cells. Microarray analysis suggested that increased intracellular [Na(+)]/[K(+)] ratio may promote the expression of cyclooxygenase-2 (COX-2), a critical enzyme in the synthesis of pr...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2020
ISSN: 0014-4835
DOI: 10.1016/j.exer.2020.107999